Protein Details: Glutamate receptor 1.2

Protein ID

ICDB_Pro_1557

Protein Name

Glutamate receptor 1.2

Gene Name

GLR1.2; At5g48400; MJE7.3

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

867 amino acids

AlphaFoldDB

AF-Q9LV72-F1-model_v4.pdb

Function

Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.

Sequence

MVRICIQTPILLSFLLVLLFFISNCFASSQNNDDDKRIRVRVGLVLDLGSVEGKIVRSSVSMALSDFYDNHNDYKTRLSLLVRDSHGEPLLALDSVVDLLQTEGVQAIIGGNSLLEAKLLAELGEKARVPVISLNSPMSLSLSKYTHLIQATHNSASEVKGITAFLHGFDWNSVALVLEDHDDWRESMHFMVDHFHENNVHVQSKVAFSVTSSEDSLMDRLRELKDLGTTVFVVHLSEVIATRLFPCAEKLGMMGEGFAWILTSRSMSSFHDQFIDDLTKEAMEGVVGFKSYIPMSKELHNFTLRWRKTLPVEEVTGSEITRLSISGVWAHDVAWSLASAAEVTRMPTVTSTLLEAIKESRFKGLSGNFQLDDMKLLSDKFEIVNMIGSGERRVGFWNSNGSFSNRRQLSSTHDNLETIIWPGGSAQSPKGRSLRESGRKKLRVLVTSSNRFPRLMKVETDPITHEITIVEGFCIEVFQASIAPFNYEVEYIRWLNGTNYTKLAYALHSQKDKYDAAVGDITITSDRSMYVDFTLPYTEMGLGIVAAKERSMWVFFQPLTPNLWITSAAFFVLTGIIVWLIERAENKEFQGSWPQQIGVVIWFGFSTLVYAHREKLQHNLSRFVVTVWVFAVLILVTSYTATLTSMMTVQQIRFNANEDYVGHLSGSLIANAALTNSSLRAMRLLGLNTSEDYAQALMNKSVSYIVSELPYLKILLGENPGHFLMVKTQSTTNGFGFMFQKGSELAPNVSREIAKLRTSERLNEMERRWFDKQLPYTTDDTSNPITLYRFRGLFMITGVSFAFALAVLLILWLRERWEILVNSVNIYFSQRLRHFRILFTRTIHPSPLGLDNPIGENAVQMAQRNRR

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed predominantly in roots and siliques

DOI ID

10.1093/oxfordjournals.molbev.a004165; 10.1093/dnares/7.1.31; 10.1111/tpj.13415; 10.1126/science.292.5521.1486b

RefSeq

NP_199651.1 [Q9LV72-1]; NP_851155.1 [Q9LV72-2]